Beilstein J. Org. Chem.2021,17, 991–1000, doi:10.3762/bjoc.17.81
-DNA by terminal stacking.
Keywords: berberinealkaloids; Cu-mediated coupling reactions; DNA recognition; nucleic acids; quadruplex DNA; Introduction
Berberine (1a) is the most prominent member of the protoberberine family, i.e., a group of tetracyclic isoquinolinium alkaloids [1]. Like many members
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Graphical Abstract
Figure 1:
Structures and numbering of berberine (1a), berberrubine (1b) and 9-O-aryl-substituted berberine de...
Beilstein J. Org. Chem.2020,16, 2795–2806, doi:10.3762/bjoc.16.230
not provide evidence for a significant effect of the adenine unit on the binding affinity of the ligands, for example, by additional association with the loops, presumably because the adenine residue is sterically shielded by the neighboring triazole unit.
Keywords: berberinealkaloids; DNA ligands
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Graphical Abstract
Scheme 1:
The structures and numbering of berberine (1a) and the alkyl-substituted derivatives 1an–en and the...